Ischemic stroke case studies


Introduction

This makes stroke the third most common cause of death in Ireland and the biggest cause of acquired disability. Ischemic stroke is more common among woman than men, with approximately 55, more women worldwide suffering a stroke than men each year.

A clot-busting drug is administered to some patients to dissolve the clot and improve blood flow to the particular area of the brain. While the drug can be quite effective if given rapidly after symptom onset within 4.

Defibrinogen Therapy for Acute Ischemic Stroke: Consecutive Cases | Scientific Reports

Recently 6 randomized clinical trials have demonstrated that patients with large occlusions do better when treated with mechanical thrombectomy than with the clot-busting drug alone. While the progress in stroke treatment has been tremendous, there is still need to improve the rate in which these thrombectomy devices re-open vessels and restore blood flow. Jump to. You are viewing the most recent version of this article. Previous versions: September 27, Previous Version 1.

Continued Study Type of Study No. Treated Interventions Treatment Results Prospec indicates prospective; ran-con, randomized controlled; retrospect, retrospective. Download figure Download PowerPoint. Disclosures None. Arch Neurol. Management of large hemispheric strokes in the neurological intensive care unit. Timing of neurologic deterioration in massive middle cerebral artery infarction: A multicenter review.

Crit Care Med. Intensive Care Med. Treatment of space-occupying cerebral infarction. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. Brain oedema in focal ischaemia: Molecular pathophysiology and theoretical implications. Ischaemic brain oedema. J Clin Neurosci.

References

Cerebral ischemia and reperfusion: The pathophysiologic concept as a basis for clinical therapy. J Cereb Blood Flow Metab. Early clinical and radiological predictors of fatal brain swelling in ischemic stroke. Predictors of fatal brain edema in massive hemispheric ischemic stroke. Treatment options for large hemispheric stroke. Osmotic therapy: Fact and fiction. Neurocrit Care. Use of mild intraischemic hypothermia versus mannitol to reduce infarct size after temporary middle cerebral artery occlusion in rats.

J Neurosurg. Multiple-dose mannitol reduces brain water content in a rat model of cortical infarction.


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Therapeutic effect of tirilazad mesylate uf , mannitol, and their combination on experimental ischemia. Res Exp Med Berl. Aggravation of vasogenic cerebral edema by multiple-dose mannitol. Mannitol for acute stroke.


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  6. Antiedema Therapy in Ischemic Stroke.
  7. Cochrane Database Syst Rev. Is there a real treatment for stroke? Clinical and statistical comparison of different treatments in patients. Mannitol use in acute stroke: Case fatality at 30 days and 1 year.

    Stroke Signs, Symptoms Treatment - Dr. Reza Jahan - UCLA Health

    Effects of hypertonic saline hydroxyethyl starch solution and mannitol in patients with increased intracranial pressure after stroke. Multimodal online monitoring in middle cerebral artery territory stroke. The effects of mannitol on cerebral edema after large hemispheric cerebral infarct. Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke. Effects of fluid management on edema volume and midline shift in a rat model of ischemic stroke. Therapy of severe ischemic stroke: Breaking the conventional thinking. Cerebrovasc Dis.

    Hypertonic saline and stroke. Treatment of cerebral edema. Hypertonic saline worsens infarct volume after transient focal ischemia in rats. Osmotherapy with hypertonic saline attenuates water content in brain and extracerebral organs. Global brain water increases after experimental focal cerebral ischemia: Effect of hypertonic saline. Hyperosmolar agents in neurosurgical practice: The evolving role of hypertonic saline.

    Circulatory and metabolic effects of glycerol infusion in patients with recent cerebral infarction. Effect of glycerol on ischemic cerebral edema assessed by magnetic resonance imaging. J Neurol Sci. Glycerol for acute stroke. High dose barbiturates in non-traumatic brain swelling: ICP reduction and effect on outcome. High-dose barbiturate therapy in humans: A clinical review of 60 patients.

    Ann Neurol. Cerebral hemodynamic effects of pentobarbital coma in head-injured patients. J Neurotrauma. The University of Toronto head injury treatment study: A prospective, randomized comparison of pentobarbital and mannitol. Can J Neurol Sci.

    Approach Considerations

    Barbiturate coma in severe hemispheric stroke: Useful or obsolete? Hyperventilation in head injury: A review. Adverse effects of prolonged hyperventilation in patients with severe head injury: A randomized clinical trial. Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury. Cerebral tissue Po 2 and SJVo 2 changes during moderate hyperventilation in patients with severe traumatic brain injury. Prolonged artificial hyperventilation in severe cerebral apoplexy.

    Clinical results and cerebrospinal fluid findings in a controlled study. Eur Neurol. Artifical hyperventilation in stroke. Trans Am Neurol Assoc. Effects of tromethamine and hyperventilation on brain injury in the cat. Effect of tris- hydroxymethyl -aminomethane on experimental focal cerebral ischemia. Exp Brain Res.

    Neurologic Worsening During the Acute Phase of Ischemic Stroke

    Pulmonary aspiration of gastric contents in patients receiving mechanical ventilation: The effect of body position. Ann Intern Med. Cerebral perfusion pressure, intracranial pressure, and head elevation. Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke. The effects of indomethacin on intracranial pressure, cerebral blood flow and cerebral metabolism in patients with severe head injury and intracranial hypertension.

    Acta Neurochir Wien. Indomethacin for brain edema following stroke. High dose steroid treatment in cerebral infarction. Effects of dexamethasone in primary supratentorial intracerebral hemorrhage.


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    Dexamethasone in acute stroke. Hypothermia in acute stroke. Curr Treat Options Neurol. Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia: Effects on neurologic outcome, infarct size, apoptosis, and inflammation. Short- and long-term outcome.

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